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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 4000! You can review the archived cases and read the suggested diagnoses by users and the final comment by the contributors.
Case are uploaded each week day by 10 am UK time with the correct diagnosis will generally be posted at 8 pm UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 2216 - 6 December 2018 Posted By: Raul Perret

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
Submitted Date :
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59 y old female with 20 mm a superficial tumor located at the flank.
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  Report Record
Go to records December 2018

User Feedback


AmerSM

Differential for me low cellular ossifying fibromyxoid tumor 1st

myxoid neurofibroma

myoepithelioma

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vincenzo

MUC4? Thinking of a LGFMS, with eterotopic focal ossification.

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John Zhang

I'd like to see S100. If positive I would consider neurothekeoma. If negative maybe LGFMS. Not too sure.

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Alex-Ventura-Leon

Alex-Ventura-Leon 0

Posted

Agree whit Vincenzo. My first possibility would be a LGFMS. Although it seems to small (20mm) and "superficial" for this entity.

Really interesting.

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Raul Perret

Raul Perret 262

Posted

Yes, this was a case of low grade fibromyxoid sarcoma with osseous metaplasia, a rare finding in this tumor. Ossifying fibromyxoid tumor is in the differential and it can also express MUC4 (although rarely), the tigroid pattern and the higher degree of atypia are the main points that help  make things apart in the present case. RT-PCR showed a FUS-CREB3L2 fusion which is quite specific for LGFMS. Have a great weekend. 

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drkhaledhindi

drkhaledhindi 0

Posted

Raul your cases are super cool and high yield.

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Raul Perret

Raul Perret 262

Posted

Happy that they are useful. Thanks for the good vibes

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