In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Sign in to follow this  

Case Number : Case 2216 - 6 December 2018 Posted By: Raul Perret

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
Submitted Date :
   (0 reviews)

59 y old female with 20 mm a superficial tumor located at the flank.

Sign in to follow this  

User Feedback


Differential for me low cellular ossifying fibromyxoid tumor 1st

myxoid neurofibroma

myoepithelioma

Share this comment


Link to comment
Share on other sites
vincenzo

Posted

MUC4? Thinking of a LGFMS, with eterotopic focal ossification.

Share this comment


Link to comment
Share on other sites
Krishnakumar subramanian

Posted

ossifying fibromyxoid tumor

Share this comment


Link to comment
Share on other sites
John Zhang

Posted

I'd like to see S100. If positive I would consider neurothekeoma. If negative maybe LGFMS. Not too sure.

Share this comment


Link to comment
Share on other sites
Alex-Ventura-Leon

Posted

Agree whit Vincenzo. My first possibility would be a LGFMS. Although it seems to small (20mm) and "superficial" for this entity.

Really interesting.

Share this comment


Link to comment
Share on other sites
Raul Perret

Posted

Yes, this was a case of low grade fibromyxoid sarcoma with osseous metaplasia, a rare finding in this tumor. Ossifying fibromyxoid tumor is in the differential and it can also express MUC4 (although rarely), the tigroid pattern and the higher degree of atypia are the main points that help  make things apart in the present case. RT-PCR showed a FUS-CREB3L2 fusion which is quite specific for LGFMS. Have a great weekend. 

Share this comment


Link to comment
Share on other sites


Create an account or sign in to comment

You need to be a member in order to leave a comment

Create an account

Sign up for a new account in our community. It's easy!

Register a new account

Sign in

Already have an account? Sign in here.

Sign In Now