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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 1997 - 31 Jan 2018 Posted By: Dr. Hafeez Diwan

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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57 year-old with right labial (vulvar) mass.


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Sort of spindle and epithelioid lesion. Granular cytoplasm but I don't think it's a granular cell tumor because granular cells don't form sheets like that. Doesn't look really malignant. Definitely needs immunostains. If it's positive for smooth muscle actin, then maybe some sort of leiomyoma or more  likely a PECOMA. But really needs immunohistochemical studies

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Dr. Richard Carr

Posted

I've added to the discussion of 1987. Hopefully Anh will spot my comments. One day Iskander might feedback his diagnosis too (tongue in cheek, smiley face!

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6 hours ago, Dr. Richard Carr said:

I've added to the discussion of 1987. Hopefully Anh will spot my comments. One day Iskander might feedback his diagnosis too (tongue in cheek, smiley face!

Thanks. Just did. Great comment as always.

I will keep doing Melan-A and SOX-10 to learn more about these stains in evaluating pigmented lesions, but apply your comment for Melan-A. I will correlate Melan-A with SOX-10.

SOX-10 is a clean nuclear stain so it's very easy to read. Even better than MiTF-1 because MiTF-1 is not as sensitive as SOX-10 in my opinion and sometimes stains nonmelanocytic cells such as macrophages / histiocytes.

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