Case Number : Case 1997 - 31 Jan 2018 Posted By: Dr. Hafeez Diwan

Sort of spindle and epithelioid lesion. Granular cytoplasm but I don't think it's a granular cell tumor because granular cells don't form sheets like that. Doesn't look really malignant. Definitely needs immunostains. If it's positive for smooth muscle actin, then maybe some sort of leiomyoma or more  likely a PECOMA. But really needs immunohistochemical studies

Dermatofibroma of granular cell type

Granular Cell Tumor. 

Vulval GCT

Agree GCT favoured

I've added to the discussion of 1987. Hopefully Anh will spot my comments. One day Iskander might feedback his diagnosis too (tongue in cheek, smiley face!

6 hours ago, Dr. Richard Carr said:

I've added to the discussion of 1987. Hopefully Anh will spot my comments. One day Iskander might feedback his diagnosis too (tongue in cheek, smiley face!

Thanks. Just did. Great comment as always.

I will keep doing Melan-A and SOX-10 to learn more about these stains in evaluating pigmented lesions, but apply your comment for Melan-A. I will correlate Melan-A with SOX-10.

SOX-10 is a clean nuclear stain so it's very easy to read. Even better than MiTF-1 because MiTF-1 is not as sensitive as SOX-10 in my opinion and sometimes stains nonmelanocytic cells such as macrophages / histiocytes.