Case Number : Case 2026 - 10 March 2018 Posted By: Limin Yu

Eosinophilic amorphous material with clefts is seen in the dermis. First possibility is of amyloidosis, either systemic or nodular. Material is too dense for lipoid proteinosis and porphyria and the site is not favoured by these conditions as well as by colloid milium and lichen amyloidosus. Not many plasma cells to call it a solitary plasmacytoma. So my diagnosis is cutaneous amyloidosis, type to be determined by clinical details.

Agree. Nodular Amyloidosis. 34betaE12?

Thanks the insightful discussion. This is a amyloidosis, confirmed by Congo red and crystal violet stains. Not knowing much about the clinical history and presentation, it is difficult to further classify it. DDx includes macular, lichen and less likely nodular amyloidosis. 

Nice case!