In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

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Case Number : Case 2026 - 10 March 2018 Posted By: Limin Yu

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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69 yo penis

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Anil Patki

Posted

Eosinophilic amorphous material with clefts is seen in the dermis. First possibility is of amyloidosis, either systemic or nodular. Material is too dense for lipoid proteinosis and porphyria and the site is not favoured by these conditions as well as by colloid milium and lichen amyloidosus. Not many plasma cells to call it a solitary plasmacytoma. So my diagnosis is cutaneous amyloidosis, type to be determined by clinical details.

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vincenzo polizzi

Posted

Agree. Nodular Amyloidosis. 34betaE12?

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Limin Yu

Posted

Thanks the insightful discussion. This is a amyloidosis, confirmed by Congo red and crystal violet stains. Not knowing much about the clinical history and presentation, it is difficult to further classify it. DDx includes macular, lichen and less likely nodular amyloidosis. 

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