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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 2073 - 17 May 2018 Posted By: Raul Perret

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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Case 56: 45 y old female with a 20-30 mm superficial lesion located in the breast.


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vincenzo polizzi

Posted

Yes! Breast Nodular Fasciitis. 

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Raul Perret

Posted

Yes well done, this is a case of nodular fasciitis of the breast. The myofibroblastic cells were positive for smooth muscle actin and negative for h-caldesmon. We also frequently perform HMGA2 that is a sensitive but unspecific maker for nodular fasciitis (in this case it was positive). Due to the presence of necrosis (figure 3), which is an infrequent finding, the referring pathologist asked for confirmation of the diagnosis by USP6 break appart FISH that was indeed positive.

Have a nice weekend

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Arash Daryakar

Posted

very nice and well documented case dear Raul.

Thanks!

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