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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 2151 - 6 September 2018 Posted By: Raul Perret

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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Breast lesion of a 60 year female with previous history of breast carcinoma treated with radiotherapy.

Edited by Admin_Dermpath


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Thought a lot about a radiation dermatitis-like AS, but not found convincing findings of it. The lymphoplasmacytic infiltrate in dermo-hypodermal junction and collagen hypertrophy make me thinking of a post-irradiation Morphea.

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Agree with Vincenzo. Rectangular outline of the biopsy piece is one more supportive point for morphea.

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Completely agree with Vincenzo. I also wondered about radiation dermatitis but favor morphea.

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Raul Perret

Posted

I am happy to agree with you all. We received this case for suspicion of radiation induced angiosarcoma which was ruled out based on morphology and negative ERG staining. I suggested that this could be a radiation induced morphea due to the box like morphology (pointed out by Mona) and the coarse collagen bundles. The lesion is also quite inflammatory as suggested by you all. The most important fact is that a neoplasm was excluded

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