Case Number : Case 2159 - 18 September 2018 Posted By: Uma Sundram

Sebaceous carcinoma in situ

intraepithelial spread of SGC suggest androgen receptor IHC

There be an added BCC to insitu Sebaceous cell Carcinoma.

Agree with sebaceous carcinoma in situ. 

Yes, in situ sebaceus carcinoma. Adipophilin should be positive.

Welcome back, Igor. 

Nice slide of sebaceous carcinoma in situ.  Any commercial US labs doing adipophilin IHC stains?  I’ve not found one.

On 18/09/2018 at 10:22, vincenzo said:

Welcome back, Igor. 

Thank you, Vincenzo. It is nice to be back to such nice cases and persons.

Yes, sebaceous carcinoma in situ. This  case was originally seen as a biopsy by a dermatopathologist, who called it SCCIS. The opthomologist discovered it was a seb ca on Mohs surgery. He was unhappy because seb ca would require a greater margin and the patient had to be taken back to surgery. So, important caveat and consideration for all lesions that look like SCCIS but are ocular or peri ocular skin. Adipophilin was positive; I would like to say for those labs without adipophilin, a combination of EMA, Ber-Ep4, and CK7 works nicely. All three are positive in seb ca but are usually negative in SCCIS.