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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 2159 - 18 September 2018 Posted By: Uma Sundram

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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65 year old woman with lesion on left eyelid.

Edited by Admin_Dermpath


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AmerSM

Posted (edited)

Sebaceous carcinoma in situ

Edited by AmerSM

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Krishnakumar subramanian

Posted

intraepithelial spread of SGC suggest androgen receptor IHC

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There be an added BCC to insitu Sebaceous cell Carcinoma.

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Yes, in situ sebaceus carcinoma. Adipophilin should be positive.

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Alice Roberts

Posted

Nice slide of sebaceous carcinoma in situ.  Any commercial US labs doing adipophilin IHC stains?  I’ve not found one.

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On 18/09/2018 at 10:22, vincenzo said:

Welcome back, Igor. 

Thank you, Vincenzo. It is nice to be back to such nice cases and persons.

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Uma Sundram

Posted

Yes, sebaceous carcinoma in situ. This  case was originally seen as a biopsy by a dermatopathologist, who called it SCCIS. The opthomologist discovered it was a seb ca on Mohs surgery. He was unhappy because seb ca would require a greater margin and the patient had to be taken back to surgery. So, important caveat and consideration for all lesions that look like SCCIS but are ocular or peri ocular skin. Adipophilin was positive; I would like to say for those labs without adipophilin, a combination of EMA, Ber-Ep4, and CK7 works nicely. All three are positive in seb ca but are usually negative in SCCIS.

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