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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 4000! You can review the archived cases and read the suggested diagnoses by users and the final comment by the contributors.
Case are uploaded each week day by 10 am UK time with the correct diagnosis will generally be posted at 8 pm UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 2166 - 27 September 2018 Posted By: Raul Perret

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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13 year old boy with an 8 cm mass located in the thigh.

Edited by Admin_Dermpath

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Raul Perret


Yes, this was a case of hybrid nerve sheath tumor (schwannoma/perineurioma). This tumors are infrequent and usually sporadic (rare cases of schwannoma/neurofibromare seen in a context of neurofibromatosis). Morphologically, in this case we see a mixture of schwann cells (eosinophilic cytoplasm and plump nuclei) and perineurial cells (slender delicate nuclei with thin delicate cytoplasmic processes). These cells are nicely remarked with s100 and EMA respectively. In addition, these lesions typically have a low proliferative index. 

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