Case Number : Case 2304 - 12 April 2019 Posted By: Dr. Richard Carr

angiosarcoma

mixed inflammatory cells in superficial and mid dermis. there are some non communicating sinusoidal vessels. some of them have prominent endothelial cells especially sen in image 4, in the dermis there are extravasted RBCs and siderophages.  may be some IHC will be useful

Angiosarcoma.

angiosarcoma

Yes, angiosarcoma.

sir, do we need a Ki 67 stain  and ERG stain to know the proliferation status before we conclude it as angiosarcoma

Yes I thought there were sufficient features here for a diagnosis of angiosarcoma. ERG should show the same irrecular branching pattern as already highlighted in the endothelial markers above. I'm not sure I'd find Ki67 helpful or definitive. We would very much have to consider the clinical context in the diagnosis.

THANKS SIR