Case Number : Case 2256 - 5 February 2019 Posted By: Uma Sundram

Combined banal and blue nevus?

I like to call it “deep penetrating nevus”. There is a small junctional component. The whole dermis is involved by the lesional cells which show no gradient or maturation phenomenon. The cells are arranged in a “Plexiform” pattern with elongated cords or oval nests of epithelioid monotonous melanocytes showing pale cytoplasm. Associated pigmented melanophages are present. In some sections, it shows growth of nevus fascicles along the eccrine glands. The stroma collagen appears undisturbed. Overall, it fits best with DPN.(though the lesion is transacted not shown the deeper aspect of the lesion)

Pigment is coarse like tattoo.

BAP1 mutation?

12 hours ago, HENRY said:

I like to call it “deep penetrating nevus”. There is a small junctional component. The whole dermis is involved by the lesional cells which show no gradient or maturation phenomenon. The cells are arranged in a “Plexiform” pattern with elongated cords or oval nests of epithelioid monotonous melanocytes showing pale cytoplasm. Associated pigmented melanophages are present. In some sections, it shows growth of nevus fascicles along the eccrine glands. The stroma collagen appears undisturbed. Overall, it fits best with DPN.(though the lesion is transacted not shown the deeper aspect of the lesion)

Full agree!!!

HELLO MONA, WELCOME BACK! MISSED YOUR COMMENTS!

7 hours ago, vincenzo said:

Full agree!!!

 

HELLO MONA, WELCOME BACK! MISSED YOUR COMMENTS!

Missed you all :-) 

Combined Nevus

Combined nevus. I like to think that there is more than one way to approach this problem. DPN vs combined nevus is all in the eye of the beholder. BAP1 is retained. Glad to see you again, Mona. You keep me honest. Hope to see you at LDS this year. 

Combined nevus.

Looks like DPN-phenotype. Nuclear-cytoplasmic beta-catenin should confirm.