Case Number : Case 2281 - 12 March 2019 Posted By: Uma Sundram

Sebaceous carcinoma

Sebaceoma

some tumor lobules shows contact with basal layer, basaxoid pattern with sebaceous differentiation, focal cracking artifact in image 4

? BCC with sebaceous differentiation-plan for complete excision

Sebaceoma  

Although, some lobules show >50% sebaceous differentiation, but focal sebaceous adenoma like differentiation may be present in sebaceoma, in such cases the distinction between sebaceoma and sebaceous adenoma is somewhat arbitrary Considering predominant basaloid proliferation in most lobules, I would prefer sebaceoma.

Benign neoplasm of sebaceous gland( sebaceous adenoma/sebaceoma-spectrum)...but with cellular atypia. Margins are near the neoplasm, but this shows a well circumscribed lobular growth pattern. So my spot, for practical reasons, is sebaceoma with atypia. I don't think this is a sebaceous carcinoma.

Sebaceoma. Need check MSI , to rule out possibility of Muir-Torre syndrome.

Sebaceoma. All MSI markers were retained, and no loss documented. The clinicians opted for complete removal.