Case Number : Case 2293 - 28 March 2019 Posted By: Raul Perret

Is that osteoid or collagen? The orange color is really interesting. I would say it's osteoid. So an osteochondrosarcomatous neoplasm. Of course, primary osteosarcoma at this age (70) is extremely unusual. So it comes down to a radiation-induced sarcoma or recurrent mammary metaplastic / sarcomatoid carcinoma. Would do a battery of cytokeratins, EMA, p63 to rule out the latter. Will need the clinical history to confirm radiation-induced sarcoma (field of radiation, when was the radiotherapy).

10 hours ago, anh said:

Is that osteoid or collagen? The orange color is really interesting. I would say it's osteoid. So an osteochondrosarcomatous neoplasm. Of course, primary osteosarcoma at this age (70) is extremely unusual. So it comes down to a radiation-induced sarcoma or recurrent mammary metaplastic / sarcomatoid carcinoma. Would do a battery of cytokeratins, EMA, p63 to rule out the latter. Will need the clinical history to confirm radiation-induced sarcoma (field of radiation, when was the radiotherapy).

Agree

Yes, Osteosarcoma is my spot and for the age should be radiaton-induced.

Metaplasic Carcinoma or Malignant Phyllodes is a still a possibility so waiting for IHC.

3 hours ago, Alex-Ventura-Leon said:

Yes, Osteosarcoma is my spot and for the age should be radiaton-induced.

Metaplasic Carcinoma or Malignant Phyllodes is a still a possibility so waiting for IHC.

Agree. Found this art.:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128365/pdf/main.pdf

post-radiation osteosarcoma.

5 hours ago, vincenzo said:

Agree. Found this art.:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5128365/pdf/main.pdf

 

Thanks for the reference article.

Indeed this was a post-irradiation osteosarcoma showing chondroblastic, fibroblastic and osteoblastic differentiation. This are aggressive tumors and in the soft tissues, around 10% are estimated to be radio-induced.