In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

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Case Number : Case 2324 - 14 May 2019 Posted By: Uma Sundram

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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51 year old female with lesion on left knee. Image 4=MITF; Image 5=p16; Image 6=Ki67

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vincenzo

Posted

Atypical Spitzoid Tumor, probably benign. Asymmetric, with focally sovrapapillary involvement and mildly expansive ( fig1 ), but without pagetoid spread or mitotic activity or other malignant features.

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John Zhang

Posted

Agree with Vincenzo that this lesion is probably benign: Spitzoid lesion with quite a few Kamino bodies, uniform atypia, no pagetoid spread, mosaic pattern of positive p16 stain. My spot is Spitz nevus, if fig1 contains nearly the entirely lesion.

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Uma Sundram

Posted

Spitz nevus. Ki67 is confined to epidermal melanocytes. However, given the age of the patient, we recommended a re excision. Hope everyone is at the LDS and having a good time. Lots of great talks!

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