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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 2326 - 16 May 2019 Posted By: Raul Perret

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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28y F, painful nodule

Edited by Admin_Dermpath


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John Zhang

Posted

Encapsulated benign nerve sheath tumor. My differential diagnosis includes intraneural neurofibroma, or schwannoma. I kind of favor neurofibroma because I see a hint of axons and mast cells. Clinical correlation, S100 and neurofilament may further differentiate the former (fusiform enlargement of the nerve; S100+ in a fraction of the cells; neurofilament highlights axons) from the later (nodular; S100+ in every cell; neurofilament-). 

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vincenzo

Posted

Neurofibromas are usually itchy but they can hurt also. This is a neurofibroma for me. 

 

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vincenzo

Posted

Many axons entrapped in the center of the lesion make me think of intraneural neurofibroma

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Raul Perret

Posted

Yes, intraneural neurofibroma. I thought it was a beautiful example 

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