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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 2331 - 23 May 2019 Posted By: Iskander H. Chaudhry

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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M47. Biopsy right cheek


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vincenzo

Posted

Triphasic pattern, with pale areas corresponding to germinal centers, surrounded by dark areas of mantle zone and by pale neoplastic areas of mz-cells admixed with many plasma cells. Some plasma cells contains intra nuclear Deutcher-bodies.

My spot is cutaneous marginal zone lymphoma..light chain restriction to confirm the diagnosis.

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Krishnakumar subramanian

Posted

reactive follicles in deep dermis with eosinophils

? psudolymphoma-tick bite/drug induced

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IgorSC

Posted

As a diffetential diagnosis, despite really rare in the skin, I would like to add cutaneous Castleman´s disease. Usually there is systemic disease associated, so I would ask for more clinical information.

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Alex-Ventura-Leon

Posted

Deep inflamation with follicles that show expansion of the marginal zone (to my eyes).

So i think in Marginal zone lymphoma too (so agree with Vincenzo)

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Lot of plasma cells. Would do IgG and IgG4 immunos. IgG4-related skin disease commonly occurs on the head and neck

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Krishnakumar subramanian

Posted

sir, whats the diagnosis

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Dr. Mona Abdel-Halim

Posted

MZL vs Lymphocytoma

Needs CD3, CD20, CD21, Bcl-2, Bcl-6, CD10 and Ki67 in addition to kappa and lambda

 

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vincenzo

Posted

So, what's the diagnosis, Dr Iskander?

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Admin_Dermpath

Posted

Dear All

 

Well done! The clinical fitted with a drug induced pseudo-lymphoma! All your differentials were great :) 

 

Iskander H. Chaudhry

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