Jump to content
In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 2406 - 19 September 2019 Posted By: Iskander H. Chaudhry

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
Submitted Date :
   (0 reviews)

18 year old female - pigmented lesion on left arm ? dysplastic.

Edited by Admin_Dermpath


  Report Record

User Feedback


We can see two types of naevus cells. One bigger, spitzoid BAP-1 negative cells, and one smaller banal type cell. These two cell components are usually BRAF mutated and area infiltrated by large amount of lymphocytes. So the diagnosis is BAP-1-inactivated melanocytic tumor. There are some familial cases in wich patients can present with multiple BAPomas, uveal melanoma and mesotheliomas.

Share this comment


Link to comment
share_externally

Admin_Dermpath

Posted

Comments from Dr Iskander Chaudhry:

Skin with polypoidal compound melanocytic proliferation with active lymphocytic inflammation. There is junctional component with mild architectural atypia. The dermal component comprises conventional naevus cells, and a population of larger epithelioid cells with vesicular chromatin, variably prominent nucleoli, abundant amphophilic cytoplasm and some pleomorphism. These latter cells demonstrate loss of nuclear BAP-1 staining on immunohistochemistry (see added!).

Diagnosis: Bapoma.

COMMENT

BAP-oma is a recently described melanocytic tumour, characterised by a mutation in the BAP-1 gene. These tumours can occur sporadically, or as part of a syndrome. Patients with a germline mutation in BAP-1 are at increased risk of other tumours including cutaneous melanoma, uveal melanoma and mesothelioma.

 

Reference: Histomorphologic spectrum of germline-related and sporadic BAP1-inactivated melanocytic tumors. Garfield EM, Walton KE, Quan VL, VandenBoom T, Zhang B, Kong BY

 

Share this comment


Link to comment
share_externally



Join the conversation

You can post now and register later. If you have an account, sign in now to post with your account.

Guest
Add a comment...

×   Pasted as rich text.   Paste as plain text instead

  Only 75 emoji are allowed.

×   Your link has been automatically embedded.   Display as a link instead

×   Your previous content has been restored.   Clear editor

×   You cannot paste images directly. Upload or insert images from URL.

Loading...

×
×
  • Create New...