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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 4000! You can review the archived cases and read the suggested diagnoses by users and the final comment by the contributors.
Case are uploaded each week day by 10 am UK time with the correct diagnosis will generally be posted at 8 pm UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 2640 - 19 August 2020 Posted By: Dr. Hafeez Diwan

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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34 year old female with inguinal lymph node biopsy. She also has a perianal lesion at the anal verge extending to labia.
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Go to records August 2020

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Krishnakumar subramanian

Krishnakumar subramanian 0

Posted

granulomatous inflammation some what emperipolesis seen if i am not mistaken

can we have macrophage markers and s 100

 

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anh

Agree. I would also add IHC for Treponema pallidum

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Meenakshi Batrani

Meenakshi Batrani 0

Posted

The pale nodule appears epithelioid to me. Could it be a metastatic deposit. 

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Dr. Hafeez Diwan

Dr. Hafeez Diwan 125

Posted

Many of the plump cells are juicy endothelial cells.  There are also plasma cells.  The treponema IHC was very positive. The perianal lesion referred to in the history was also positive for spirochete.  So this was syphilis involving the lymph node.

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Krishnakumar subramanian

Krishnakumar subramanian 0

Posted

Thanks a lot Dr

Basic rule whenever there are plasma cells get serology done

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