Case Number : Case 2588 - 08 June 2020 Posted By: Iskander H. Chaudhry

SCCIS / Paget’s disease 

4 hours ago, Hamad said:

SCCIS / Paget’s disease 

Agree.

I would do immunohistochemistry to differentiate pagetoid neoplasms such as: Bowen's disease, Paget's disease (I believe to be one of these two), sebaceous carcinoma, among others.

agree could be Bowen's or Paget's disease

Agree with the above mentioned possibilities, in situ seb carc also

Hello everyone.  I have been one of the "silent majority" not putting my head above the parapet for the last few years.  Retirement from Dermatological practice and "lockdown" has given me lots of time to study this wonderful website, and I would like to say a collective thank you to all the erudite contributors who have educated and entertained me in equal measure.

Regarding this case, the action is clearly in the epidermis and I agree that Bowen's or Paget's disease are the most likely diagnoses.  However, Iskander has shown several views of the sebaceous glands, so I wonder what his final thoughts on this case were?

Dear All 

The final diagnosis is Clear Cell Bowen's based on immunochemistry. I exclude Paget's and also MMIS. The sebaecous gland photomicrographs I added for you to consider sebaceous carcinoma in situ which there was not compelling evidence of on morphology or immunochemistry. A panel of markers  for sebaecous differentiation include: EMA, CK7, Ber-EP4, Factor XIIIA, androgen receptor, p53, adipophilin, progesterone receptor membrane component 1 (PGRMC1), squalene synthase (SQS), and alpha/beta hydrolase domain-containing protein 5 (ABHD5) :).