Case Number : Case 2601 - 25 June 2020 Posted By: Saleem Taibjee

Difficult, without any evidence of glandular differentiation and mucin secretion.Some salt and pepper appearance of nuclei in last picture. Favor EMPSGC.

1 hour ago, vincenzo said:

Difficult, without any evidence of glandular differentiation and mucin secretion.Some salt and pepper appearance of nuclei in last picture. Favor EMPSGC.

Agree

Here are some immunostains

The immunohistochemistry would support the suggested diagnosis of EMPSGC.

Lovely EMPSGC

Nice case. Thank you for sharing!

Yes, well done, this is Endocrine mucin-producing sweat gland carcinoma. In addition to the cytological clues which Vincenzo points out, the impression of dyscohesion / 'falling apart' is helpful, as well as the characteristic location on the eyelid. As in this case, mucin and glands can be hard to identify.

This is referred to as a carcinoma, with a possibility of local recurrence, but there have been no instances of metastasis reported as far as I know.

thanks for the interesting case Dr