Case Number : Case 2582 - 29 May 2020 Posted By: Dr. Richard Carr

Spitz tumor, favor benign.

1 hour ago, vincenzo said:

Spitz tumor, favor benign.

Agree!

Compound Spitz nevus. 

The neoplasm is symmetrical, with scarcity of pagetoid ascension. The patient, although an adult, is still young.

Spitz nevus or Reed's nevus

spitz nevus

I found this case quite challenging. History was longstanding pigmented lesion increase in shade of pigmentation. There were two mitoses in one of the sections, both superficial. p16 mosaic (wild) throughout and low Ki67 are somewhat re-assuring. Originally I favoured a benign compound naevus with an epithelioid clone (clonal naevus, phenotypic heterogeneity) but I made a note in my database that it is probably a Reed-naevus (Spitz variant). Small lesions that are clinically suspicious are often highly challenging and obviously complete excision with clear margins is recommended ab initio if there are any clinical concerns.

Lovely!