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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 2705 - 18 November 2020 Posted By: Dr. Hafeez Diwan

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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66 day-old deceased male with widespread hyperkeratotic plaques and papules. He had a sibling who died at the age of 6 months.


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Krishnakumar subramanian

Posted

Epidermolytic hyperkeratosis, the sibling would have bullous congenital ichthyosiform erythroderma 

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Agree. Moreover, there are some nuclear inclusion bodies in last picture, Parvo virus-like, I cannot grasp. 

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Krishnakumar subramanian

Posted

must we think of  SAM syndrome here, where epidermolytic hyperkeratosis can be seen. genetic studies can help in final diagnosis

Severe skin dermatitis, multiple allergies and metabolic wasting (SAM) syndrome is a rare life‐threatening inherited condition caused by bi‐allelic mutations in DSG1 encoding desmoglein 1. The disease was initially reported to manifest with severe erythroderma, failure to thrive, atopic manifestations, recurrent infections, hypotrichosis and palmoplantar keratoderma

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