Case Number : Case 2711 - 26 November 2020 Posted By: Saleem Taibjee

BCC, probably infundibular variant, with an odd signet ring cell component. Very intriguing lesion. 

collision tumour?BCC and balloon cell naevus.I would do s100/mel a

BCC with another tumor ? collision tumor

really dont know

Signet-ring clear cell basal cell carcinoma. I wonder whether this tumor shows myoepithelial differentiation.

Mixed micro-nodular BCC and granular cell variant of BCC.  Looks similar to case 564 posted on 7th August 2012.

Nodular BCC with some kind of granular cell differentiation.

Yes, I thought that this best fits for BCC with granular cell change. The cytoplasm is definitely granular rather than just clear, although perhaps such cases fall on a spectrum.

This must be extremely rare. I do not recall seeing such a case previously.

The case looks very similar to this published case https://pubmed.ncbi.nlm.nih.gov/24247582/ and is even more striking compared to the case which Richard points out was posted in 2012. In the published case the cells were positive for BerEP4 and CD68. However, I must admit that we did not run any immunos in the current case. The nuclei seem identical to the more conventional BCC areas, hence I was not considering a collision (e.g. melanocytic lesion, etc). BW Saleem

Great Case, Saleem. Thanks a lot.