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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 2687 - 23 October 2020 Posted By: Dr. Richard Carr

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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M85. Conjunctiva. Bladder cancer 2 years ago. ?Secondary


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The superficial component would better fit a primary conjunctival case...

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Victor Delgado

Posted

Agree with @vincenzo, favors primary cutaneous tumor, could be Mucoepidermoid Carcinoma

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Dr. Richard Carr

Posted

I also called this mucoepidermoid carcinoma. In this paper they state that these lesions are not true mucoepidermoid carcinomas.

https://www.nature.com/articles/s41379-020-0456-9

I guess we'd have to do more studies to confirm if this example is just "adenosquamous carcinoma".

Interestingly there is a complete knock-out of p16 staining (Null). Note mosaic pattern in entrapped ducts. We've found mutant patterns for p16 in over 80% of cutaneous SCCs. Even higher rate in actinic keratosis & bowenoid dysplasias (>90%). The diagnostic utility of this has not been recognised till now and we need to publish our audit findings soon!

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