Case Number : Case 2688 - 26 October 2020 Posted By: Iskander H. Chaudhry

Epithelioid haemangioma (angiolymphoid hyperplasia with one eosinophil!).

What are the ganglion-like cells?

Angiomatoid Spitz Nevus

Angiomatoid/ desmoplastic Spitz nevus.

Totally agree with Victor and Eman...but this case is difficult, because of:

1) pz age

2) lymphocytic infiltrate, usually found in DMM ( but also found in DSN ). 

In short, my spot is Desmoplastic ( H-RAS? ) Spitz Nevus. 

Desmoplastic Spitz nevus

which is better S100 or Sox 10 sir

Iskander, what was the final diagnosis please?

Dear All 

Please see my comments:

Skin with a non-ulcerated symmetrical intradermal melanocytic lesion. The dermal nests are
composed of epithelioid cells with large nuclei, small nucleoli and abundant cytoplasm. The
epidermis is mildly acanthotic. The dermal component shows maturation with depth and prominent
fibrosis around the dermal nests. No mitoses are seen. The proliferation index is low.

The features are those of a desmoplastic Spitz naevus and given the age of the patient this lesion is
considered atypical and MDT discussion is advised.

typical desmoplastic Spitz naevus at and uncommon age.