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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 4000! You can review the archived cases and read the suggested diagnoses by users and the final comment by the contributors.
Case are uploaded each week day by 10 am UK time with the correct diagnosis will generally be posted at 8 pm UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 2820- 28 April 2021 Posted By: Iskander H. Chaudhry

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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Left of vertex, PB. The whole lesion evacuated once punch biopsy undertaken. Enlarging nodule erythematous, non-scaly. Previous SCCs. Softy mushy bloody tissue.

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Posted (edited)

High grade tumour with osteoclast-like giant cells. IHC needed here, could be poorly differentiated sarcomatoid SCC in view of the history, undifferentiated pleomorphic sarcoma with osteoclast component is also in the differential. 

I agree would also include AFX here. Needs some CPC and correlation with imaging.

Edited by daniellindsay

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Meenakshi Batrani

Posted (edited)

Seems to be high grade malignant neoplasm rich in vasculature. I would keep a differential of epithelioid angiosarcoma, metastasis such as renal cell carcinoma. Needs IHC markers. Yes, AFX also in differential

Edited by Meenakshi Batrani

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Thank you. Yes this was an interesting case of a sarcomatoid carcinoma with osteoclast like giant cells
 Previous history of spindle
Cell carcinoma

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