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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 4000! You can review the archived cases and read the suggested diagnoses by users and the final comment by the contributors.
Case are uploaded each week day by 10 am UK time with the correct diagnosis will generally be posted at 8 pm UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 2905 - 25 August 2021 Posted By: Uma Sundram

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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79 year old male with bilateral eyelid masses.
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Go to records August 2021

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Meenakshi Batrani

Meenakshi Batrani 0

Posted (edited)

I think it is one of the Adult orbital xanthogranulomatous diseases, which is of 4 types : adult onset xanthogranuloma , adult onset asthma with periocular xanthogranuloma, Erdheim-Chester disease, and necrobiotic xanthogranuloma. Histologically all 4 types are overlapping, the distinction relies on clinical correlation.

Edited by Meenakshi Batrani

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Krishnakumar subramanian

Krishnakumar subramanian 0

Posted

agree, also add Rosai dorfman disease, IHC panel is needed as prognosis and further lab investigations are different in each

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Uma Sundram

Uma Sundram 169

Posted

Adult onset periorbial XG. Rosai dorfman was excluded via IHC. Patient currently being worked up for erdheim Chester dz as there are some bone changes as well.

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Krishnakumar subramanian

Krishnakumar subramanian 0

Posted

 BRAF V600 mutation data is it necessary

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