Case Number : Case 2756 - 28 January 2021 Posted By: Dr. Mona Abdel-Halim

HPV infection. 

Most likely one of the HPV types associated with common flat warts such as HPV3. 

I have noticed that this is often called epidermodysplasia verruciformis (EDV) by pathologists.  This is confusing, because clinicians would only use the term EDV for very rare cases of a genetically inherited predispostion to widespread flat warts associated with a wide variety of rare HPV types.

I will admit that I would call this epidermodysplasia verruciformis, but if the clinician describes it as an isolated lesion, than I would probably call it "EV acanthoma", as suggested in Mckee's pathology of the skin.

That makes more sense.

This was typical case of epidermodysplasia verruciformis

Mona, by "typical" do you actually mean a case of the very rare genodermatosis epidermodysplasia verruciformis (EDV), or was this a common, plane wart in an otherwise normal patient?  Histologically of course the lesions look the same, but the implications of labelling a patient with EDV are significant.

Dear Dr Richard

This was a male 27 who had generalized TV-like and plane wart like lesions progressively developing since childhood. His presentation fits with the genodermatosis EDV.