Case Number : Case 2778 - 1 March 2021 Posted By: Iskander H. Chaudhry

Same case as 2775 (24 february)

6 hours ago, Alex-Ventura-Leon said:

Same case as 2775 (24 february)

Yes, although the exposure is much better this time.  Iskander - what's the verdict on this one?

Sebaceoma

I will call it seb carc

The lesion has expansive growth and, despite the mitotic activity, the cells are monomorphic. I get the diagnosis of Sebaceoma.

Sebaceoma

Yes, interesting discussion. This is a sebaecous tumour and the question is sebaceoma versus well diff seb carcinoma. I accept porocarcinoma is in the differential but I felt there was definite sebaceous differentiation. You can see increase mitotic activity in a sebaceoma, however, this is typically spare. Stigmata for carcinoma are prominent nucleoli, mitotically activity and pleomorphism - necrosis is a helpful feature. Deep extension, adnexal or lymphovascular invasion are all seen in carcinoma. 

This was reported as favouring an extra-ocular well differentiated sebeacous carcinoma.