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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 2791- 18 March 2021 Posted By: Saleem Taibjee

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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69F – biopsy of lesion right labia (vulva)


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Richard Logan

Posted

Adenocarcinoma with Pagetoid spread.

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yuriy shatovsky

Posted

Squamosus cell non-keratizing invasive carcinoma .

 

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EMPD-associated Apocrine Adenocarcinoma, with vascular invasion. 

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Meenakshi Batrani

Posted

Apocrine adenocarcinoma with pagetoid spread

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Krishnakumar subramanian

Posted

apocrine adenocarcinoma with pagetoid spread

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Saleem Taibjee

Posted

This is a case of primary, invasive, extramammary Paget's, courtesy of my colleague Mohamed Satti.

It is a challenging case in so far as the intraepidermal component is so florid that at first sight one might not appreciate the Pagetoid nature of a subpopulation of cells distinct to the resident keratinocytes, with a potential misdiagnosis as squamous cell carcinoma / adenosquamous carcinoma. We nearly fell into this trap.

Various immunostains were performed, mainly in excluding secondary causes (from an internal malignancy). Positive staining included: CK7, BerEP4, GATA3, GCFDP15, CEA, Her2. Negative stains included CK20, CDX2, ER, PR, PAX8.

BW

Saleem

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