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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 4000! You can review the archived cases and read the suggested diagnoses by users and the final comment by the contributors.
Case are uploaded each week day by 10 am UK time with the correct diagnosis will generally be posted at 8 pm UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 2963 - 15 November 2021 Posted By: Dr. Mona Abdel-Halim

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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F, 58 ,Progressive course of multiple hard cutaneous and sub-cutaneous nodules involving the scalp, nape and trunk of around 1 year duration. The skin condition is associated with difficulty in breathing. A recent chest X-ray revealed multi-focal patchy ill-defined ground glass opacities in different segments of both lungs. A biopsy was taken from one of the trunk lesions.

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First spot: Mts of cribriform adenocarcinoma of the lung ( ttf1? ck7? ). 

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This will require extensive investigations. Is it a carcinoma of the lung metastatic to the skin or some other internal malignancy metastatic to lungs and skin needs to be considered. 

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Dr. Mona Abdel-Halim


Cutaneous metastatic cribriform adenocarcinoma. This was CK7 positive, CK 20 negative, ER positive, PR positive. Further work up confirmed the breast as the origin. 



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