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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 4000! You can review the archived cases and read the suggested diagnoses by users and the final comment by the contributors.
Case are uploaded each week day by 10 am UK time with the correct diagnosis will generally be posted at 8 pm UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 2911 - 02 September 2021 Posted By: Dr. Hafeez Diwan

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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74 year-old female with biopsy of left calf: cyst vs panniculitis vs other.

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Richard Logan


This image is hard to interpret.  I think it has been digitally manipulated to brighten it up which distorts the colour reproduction.  There appears to be an area of possible mucinous degeneration or oedema in the dermis.  I cannot think of a form of amyloidosis that would present on the calf and be misinterpreted as a cyst or panniculitis.  I don't know what it is, but I think we are not seeing an accurate version of what Hafeez Diwan saw down his microscope.

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Eman El-Nabarawy


Myxomatous stroma, atrophy of the epidermis, scattered spindle-shaped and stellate fibroblasts, and collagen-fiber dissociation (cleft-like spaces), Solitary cutaneous focal mucinosis. 


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