Case Number : Case 3069 - 12 April 2022 Posted By: Uma Sundram

Dusty cytoplasm, fascicular growth, bland cytology, no mitotic activity. favor DPN, would use beta-catenin for confirmation.

DPN

24 minutes ago, Shawn said:

Dusty cytoplasm, fascicular growth, bland cytology, no mitotic activity. favor DPN, would use beta-catenin for confirmation.

Concur

9 hours ago, Mohamed khaled said:

DPN

Can it have multinucleated giant cells? 

Can DPN have multinucleated giant cells? Sorry for my ignorance; have just seen one case in the past

8 hours ago, Chirag Desai said:

Can DPN have multinucleated giant cells? Sorry for my ignorance; have just seen one case in the past

Although it is not common finding, multinucleated cells are reported in DPN 

DPN. Beta catenin is positive.

Deep penetrating nevus.

13 hours ago, Mohamed khaled said:

Although it is not common finding, multinucleated cells are reported in DPN 

thanks

10 hours ago, Uma Sundram said:

Deep penetrating nevus.

how do we differentiate this lesion from cellular blue nevus?

13 hours ago, Chirag Desai said:

how do we differentiate this lesion from cellular blue nevus?

Cellular blue nevus: look for adjacent common blue nevus component, lacks nuclear beta-catenin staining, less dusty cytoplasm.

7 hours ago, Shawn said:

Cellular blue nevus: look for adjacent common blue nevus component, lacks nuclear beta-catenin staining, less dusty cytoplasm.

Ok, Thanks a lot for the explanation.