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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 3034 - 22 February 2022 Posted By: Uma Sundram

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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59 year old male with longitudinal melanonychia of his right middle finger.


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Meenakshi Batrani

Posted

In these H&E images there appears to increase in epidermal melanin with some melanin incontinence. Could just be hypermelanosis or melanotic macule but IHC is needed to assess if there is any increase in melanocyte density to check for nail lentigo and also to exclude nail MMIS which can be very subtle. 

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Uma Sundram

Posted

Great point, especially in this age group. This was exactly our problem. Sox 10 highlighted a normal number of melanocytes. Diagnosis= nail lentigo.

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