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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 4000! You can review the archived cases and read the suggested diagnoses by users and the final comment by the contributors.
Case are uploaded each week day by 10 am UK time with the correct diagnosis will generally be posted at 8 pm UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 3014 - 25 January 2022 Posted By: Uma Sundram

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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75 year old female with multiple lesions on the left leg.

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Pilar leiomyomas. Useful a HP-magnification to watch to nucleoli, so we can rule out Hereditary Leiomyomatosis( FH-mutation related ). I’m not able to see the prominent nucleoli with clear perinucleolar space, at these magnifications. Maybe negative. 

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Sorry. Not able to delete this comment. The above comment is my spot diagnosis. 

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Uma Sundram


Our concern also was hereditary leiomyomatosis syndrome, which we could not exclude based on morphology. A reminder that multiple leiomyomata can be syndromic, and should prompt us to alert the clinician.

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