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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 4022 - 21 June 2022 Posted By: Uma Sundram

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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69 year old female with diffuse macular rash.


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Anil Patki

Posted (edited)

Subcorneal clevage with neuts and eos. Acute generalized exanthematous pustulosis (early stage as the lesions are macular) is likely. Staphylococcal scalded skin syndrome can occur in adults with renal impairment. Pemphigus foliaceus is the third possibility. Clinicopathological correlation , DIF and anti Dsg 1 and Dsg3 tests will help.

Edited by Anil Patki
spelling mistake

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volha

Posted

Neut rich subcorneal blister and also eosinophils

AGEP or Drug reaction?

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vincenzo

Posted

I think this could be a neutrophils rich variant of pemphigus Foliaceus. 

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Krishnakumar subramanian

Posted

could be all 2 such as Neutrophil rich PF or AGEP

some lab investigations are needed

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Krishnakumar subramanian

Posted

morphology -does not support AGEP more of pemphigus foliaceous

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