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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 1700! You can review the archived cases and read the suggested diagnoses by users and the final comment by Dr Uma Sundram, the Editor-in-Chief and main spot diagnosis host. Case are uploaded each week day by 10 a.m. UK time with the correct diagnosis will generally be posted at 8 p.m. UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 3043 - 07 March 2022 Posted By: Dr. Mona Abdel-Halim

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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M, 63,Progressive development of reddish-brown nodules and tumorous plaques over both cheeks and the right ear of about 2 months duration. Two ill-defined low grade metabolically active mesenteric nodal masses appeared in PET-scan.


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Shawn

Posted

Low power: blue dots in a sea of pink; histiocytic lesion with CD68 and S100 co-expression - Rosai-Dorfman disease. Though this one seems neutrophil rich, usual RDD would be more lymphoplasmacytic... Exclude infectious etiologies with special stains/culture?

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msofopoulos

Posted

I think i see emperipolesis. It could be Rosai Dorfman. The few cases i have seen had a more intense s100 stain

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Meenakshi Batrani

Posted

Agree with RDD

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Basma

Posted

Very beautiful case. Rosai dorfman dis.

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Basma

Posted

Rosai dorfman dis. Very beautiful case.

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IgorSC

Posted

On 07/03/2022 at 13:07, Shawn said:

Low power: blue dots in a sea of pink; histiocytic lesion with CD68 and S100 co-expression - Rosai-Dorfman disease. Though this one seems neutrophil rich, usual RDD would be more lymphoplasmacytic... Exclude infectious etiologies with special stains/culture?

Agree

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vincenzo

Posted

the The blue-pink contrasted areas, as well pointed out by Shawn and Igor, are in keeping with a RDD diagnosis. 

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Dr. Mona Abdel-Halim

Posted

Thank you all! Yes, this was a beautiful example of RDD. 

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