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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 4000! You can review the archived cases and read the suggested diagnoses by users and the final comment by the contributors.
Case are uploaded each week day by 10 am UK time with the correct diagnosis will generally be posted at 8 pm UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : Case 4194 - 16 February 2023 Posted By: Iskander H. Chaudhry

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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79 M, Left wrist incision biopsy. Subcutaneous nodule with papular appearance on epidermis 1.5cm x
1cm ??malignancy / metastatic lesion to exclude MM

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Anil Patki


The dermis shows mucin and pleomorphic cells lying singly and in glandular formations. The epidermis shows irregular acanthosis and clear cells lying singly within it. I think this is metastatic mucinous adenocarcinoma with epidermotropism. Investigations for the primary malignancy and some additional IHC (CK7, CK20, p63, S100) needed 


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?MyxoInflammatory Fibroblastic Sarcoma. 

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