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In this section we have spot diagnoses posted on a daily basis since June 2010, now over 4000! You can review the archived cases and read the suggested diagnoses by users and the final comment by the contributors.
Case are uploaded each week day by 10 am UK time with the correct diagnosis will generally be posted at 8 pm UK time. Why not view the most recent spot diagnosis and proffer a diagnosis?

Case Number : CASE 4480 - 22 March 2024 Posted By: Admin_Dermpath

Please read the clinical history and view the images by clicking on them before you proffer your diagnosis.
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84-year-old woman with two purple nodules of the left calf grown rapidly in five months.
Contributor: Pr. Béatrice VERGIER

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Anil Patki


Diffuse large B cell lymphoma leg type - to be confirmed by IHC.

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Thank you for your comments. 

The final diagnosis is: Primary cutaneous follicle centre B-cell lymphoma, large-cell predominant

The differential diagnoses to consider are:

CD30 anaplastic T-cell lymphoma
Large B-cell lymphoma leg-type
Diffuse large B-cell lymphoma
Blastic plasmacytoid dendritic cell neoplasm

I have uploaded the immunochemistry of this case also.

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