Combined tumours

Case 972  14.3.14  (R. Carr)  F 51 ?dysplastic naevus 

BCC confirmed by Ber-EP4 and CD10 arising in a dysplastic naevus. 

Detailed discussion on combined baso- and squamo-melanocytic “combined” tumours, and on use of CD10 to distinguish between BCC, trichoepithelioma and trichoblastoma 

Case 1867  25.7.17 (IH Chaudhry)  F 22 nose – changing mole 

Combined intradermal naevus and trichoepithelioma. 

Discussion about whether to follow the WHO classification of skin tumours in which  trichoblastoma is every adnexal cutaneous tumour with differentiation toward both follicular germinative epithelium and specific follicular stroma. Trichoepithelioma is merely a synonym for some microscopic variants of trichoblastoma.  Also reference to follicular induction overlying a naevus (R. Perret) 

Case 1920  9.10.17  (L. Yu)  M 62 finger 

Haemangioma + Masson’s tumour. 

Case 1923  12.10.17 (R. Carr)  M 85 ear 

Hyperkeratotic papillomatous warty lesion with two distinct pathologies.  More basophilic area of irritated seb wart.  More eosinophilic areas with ducts indicating a poroid variant of poroma/hidradenoma.  Advances theory that seb wart arises from follicular infundibulum, as they don’t occur on glabrous, non-hair bearing skin such as palms and soles. 

Case 2105  2.7.18  (L.Yu)  F 40 vulval lesion Condyloma (genital wart) and syringoma 

Dual pathology.  Acanthosis; koilocytosis.  Signs more subtle than viral wart on non-genital skin. 

Case 2672  2.10.20 (R. Carr) F 35 new pigmented lesion below eye 

Common intradermal naevus and DPN.  Beta-catenin +ve in cytoplasm and nuclei of the DPN clone.  Complex discussion of staining and mutation patterns in these types of pigmented lesions. 

Case 4069  25.8.22 (S. Taibjee) F 90 ?BCC right nostril 

Trichoepithelioma (CD10 highlighting papillary mesenchymal cells in TE component), and tubular apocrine adenoma (CEA highlighting ducts in glandular component).