Endocrine mucin-producing sweat gland carcinoma (EMPSGC)

Case 1818 17.5.17  (H. Diwan)  F 59 infra-orbital lesion.  Known to have metastatic parotid ca. 

Features of both this entity and mucinous carcinoma, as primary skin tumour, not metastasis from parotid.  See discussion in 1669, mucinous carcinoma. 

Case 1898 6.9.17 (H. Diwan)  F 70 nodule eyelid 

Solid, lobulated tumour with rosettes of mucin-producing cells.  Not very pleomorphic. Very similar to 1669 – primary cutaneous mucinous carcinoma. 

Case 2108  5.7.18 (H. Diwan)  70 facial “cyst” 

Multinodular tumour with fibrovascular core, cystic ducts and mucinous stroma.  Looks like solid papillary breast carcinoma. 

DD: adenoid cystic carcinoma – this is more basaloid with basement membrane-like material around tumour nests. 

Case 2183  22.10.18  (L. Yu)  F  59 eyelid (typical site) 

Rare adnexal tumour with low grade cytological features and neuroendocrine differentiation.  Analogous to solid papillary carcinoma of breast.  Nodular, solid, papillary and/or cribriform architecture, neuroendocrine differentiation and mucin production.  ER and PR +ve. Synaptophysin +ve. Chromogranin –ve. 

Ref:  Brett,M.  Case Rep Pathol 2017 Art ID: 6543709 

Case 2601   25.6.20  (S. Taibjee)  F  55 cyst lower eyelid 

Solid and cystic tumour.  Cells look rather bland with not a great deal of pleomorphism.  Discohesive (falling apart).  Mucin and ducts not visible (often hard to identify in this entity).  Eyelid characteristic site. 

Case 2817  23.4.21 (R. Carr) F 70 eyelid “cyst” 

Identical cytology to case 2601 above.  Neuroendorcine markers including synaptophysin can be quite variable, focal and weak as in this case. 

Case 4504 25.4.24 (S. Baksh) M 66 eyelid lesion 

Case 4512  7.5.24 (U. Sundram) M 91 eyelid lesion 

INSM1 strongly +ve. INSM1 is a transcription factor protein which is increasingly used as an immunohistochemical marker for neuroendocrine differentiation. 

Case 4509 2.5.24 (J Costa-Rosa) M 83 papule, eyelid 

Case 4559 11.11.24 (J Costa-Rosa) F 74 Scalp tumour 

Cystic, glandular structure. In-situ component detected by p63 – primary skin tumour